【佳學基因檢測】CRISPR/Cas9 引導的表觀遺傳調控對神經精神疾病的潛在治療意義

靶向藥一個月費用排序

閱讀神經系統啟動預防及反復抑制基因檢測聽到《Curr Top Med Chem》在.?2021;21(10):878-894.發(fā)表了一篇題目為《CRISPR/Cas9 引導的表觀遺傳調控對神經精神疾病的潛在治療意義》腫瘤靶向藥物治療基因檢測臨床研究文章。該研究由Desh D Singh, Ravi Verma, Piyush Parimoo, Ashish Sahu, Vikram Kumar, Era Upadhyay, Dharmendra K Yadav等完成。促進了腫瘤的正確治療與個性化用藥的發(fā)展，進一步強調了基因信息檢測與分析的重要性。

精神科神經科致病基因及正確治療臨床研究內容關鍵詞：

GWAS,動物模型,雙極,會聚功能基因組學,基因表達

精神科心理科疾病用藥指導基因檢測臨床應用結果

腦功能活動受遺傳和表觀遺傳因素的幾種機制的調節(jié)，例如組蛋白建模、DNA 甲基化和非編碼 RNA。這些調節(jié)機制的改變會影響導致神經精神疾病 (ND) 的神經元的正常發(fā)育。然而，需要分析與分子機制相關的神經精神疾病的功能意義，以在患者的早期診斷和治療中帶來治療進展。 CRISPR/Cas 9（Clustered Regularly Interspaced Short Palindromic Repeats）基因組編輯工具同時有效改變了多個基因組和表觀基因組操作目標。本綜述討論了在 ND 的分子機制中使用 CRISPR/Cas 9 工具作為一種治療方法來克服由遺傳和表觀遺傳異常引起的 ND 的可能性。表觀遺傳規(guī)律；基因編輯；神經元發(fā)育；神經精神疾??；治療應用。轉錄因子。

神經及精神疾病及其并發(fā)征、合并征國際數據庫描述：

Brain function activity is regulated by several mechanisms of genetic and epigenetic factors such as histone modelling, DNA methylation, and non-coding RNA. Alterations in these regulatory mechanisms affect the normal development of neurons that causes Neuropsychiatric Disorders (ND). However, it is required to analyse the functional significance of neuropsychiatric disorders associated with a molecular mechanism to bring about therapeutic advances in early diagnosis and treatment of the patients. The CRISPR/Cas 9 (Clustered Regularly Interspaced Short Palindromic Repeats) genome editing tools have revolutionized multiple genome and epigenome manipulation targets the same time. This review discussed the possibilities of using CRISPR/Cas 9 tools during molecular mechanism in the ND as a therapeutic approach to overcome ND that is caused due to genetic and epigenetic abnormalities.Keywords:?CRISPR/Cas9; Epigenetic regulations; Gene editing; Neuronal development; Neuropsychiatric Disorders; Therapeutic applications.; Transcription factor.