受精（Fertilization）
當(dāng)精子和卵細(xì)胞結(jié)合產(chǎn)生合子（或者是）受精卵時(shí)，這就是受精過(guò)程。當(dāng)受精卵向子宮移動(dòng)時(shí)，開(kāi)始分裂過(guò)程。
基因解碼準(zhǔn)備
了解人的受精過(guò)程
受精過(guò)程的核心要點(diǎn)
要點(diǎn)
- 受精通常叫做懷孕，一旦受精卵在子宮內(nèi)壁上著床，妊娠就開(kāi)始了。
- 精子和卵細(xì)胞的結(jié)合通常在性交后發(fā)生，但是人工受精和體外受精可以在沒(méi)有性交活動(dòng)的情況下實(shí)現(xiàn)妊娠。
- 受精過(guò)程由多個(gè)buchou組成，任何一步發(fā)生障礙都會(huì)導(dǎo)致妊娠失敗。
- 在受精前，精子在女性生殖道的環(huán)境的刺激下，通過(guò)獲能增加運(yùn)動(dòng)能力、降低細(xì)胞膜的穩(wěn)定性，使得精子的頭部可以進(jìn)入卵子。
人體疾病及表征術(shù)語(yǔ)（Key Terms）
- 受精（fertilization）: 精子和卵細(xì)胞的集合過(guò)程。
- 獲能（capacitation): 精子在女性生殖里獲得進(jìn)入使卵細(xì)胞受精的能力的過(guò)程。
- 植入（implantation）: 受精卵嵌合進(jìn)入子宮壁的過(guò)程。
- 不分離（Nondisjunction）: 在細(xì)胞分裂過(guò)程中，同源染色體和姊妹染色單體沒(méi)有正常分離的現(xiàn)象。
- 合子（zygote）: 受精的卵細(xì)胞。
如果妊娠過(guò)程是從植入開(kāi)始，導(dǎo)致妊娠的雌性配子或者是卵細(xì)胞與雄性配子或者是精子的結(jié)合則發(fā)生在更早的時(shí)候。在醫(yī)學(xué)上，這個(gè)過(guò)程叫做受精，用非專(zhuān)業(yè)的話(huà)來(lái)講，也就是通俗的說(shuō)，就是受孕。
受精后，雄性配子和雌性配子的結(jié)合產(chǎn)物被稱(chēng)為合子或者受精卵。對(duì)于人來(lái)說(shuō)，采用的是體內(nèi)受精過(guò)程，雌性和雄性配子的結(jié)合實(shí)際上發(fā)生在性交之后。
但是，人工受精和體外受精的出現(xiàn)，使得沒(méi)有性交過(guò)程也可以開(kāi)啟妊娠。這個(gè)方法可以是自愿選擇，也可以是因?yàn)椴挥脑颉?/p>
人類(lèi)的受精: 精子和卵細(xì)胞通過(guò)受精而結(jié)合產(chǎn)生合子，在8天左右，合子植入到子宮壁上，長(zhǎng)達(dá)9個(gè)月。
受精過(guò)程有多個(gè)bucu，其中任何一個(gè)收到干擾都會(huì)導(dǎo)致失敗。在這個(gè)過(guò)程的開(kāi)始，精子經(jīng)過(guò)一系列的變化，因?yàn)閯倓偵涑龅木硬荒軌蚴芫蛘呤芫芰Σ蛔恪?/p>
精子在女性生殖道里，經(jīng)過(guò)幾個(gè)小時(shí)的獲能的過(guò)程，增加運(yùn)動(dòng)能力，降低膜的穩(wěn)定性。通過(guò)降低膜的穩(wěn)定性，精子為頂體反應(yīng)做好準(zhǔn)備。頂體反應(yīng)穿過(guò)堅(jiān)硬的透明帶膜的酶促反應(yīng)過(guò)程。精子和從兩個(gè)卵巢中的一個(gè)釋放出來(lái)的卵細(xì)胞在輸卵管（fallopian tubes）結(jié)合。
受精卵，又稱(chēng)為合子，然后移動(dòng)到子宮，這個(gè)行程需要近一個(gè)星期的時(shí)間，才能植入到子宮壁上。通過(guò)受精，卵細(xì)胞活化，開(kāi)啟發(fā)育過(guò)程，完成第二次減數(shù)分裂，兩個(gè)單倍體核結(jié)合在一起形成新的二倍體的基因組。
減數(shù)分裂過(guò)程中的不分離及從合子到囊胚的早期分裂過(guò)程的出現(xiàn)的問(wèn)題會(huì)導(dǎo)致無(wú)法植入或者是妊娠失敗。
Cleavage of the Zygote
The process of cleavage is the step of embryogenesis where the zygote divides to produce a cluster of cells known as the morula.
LEARNING OBJECTIVES
Describe cleavage of the zygote
KEY TAKEAWAYS
Key Points
- Following fertilization a series of rapid cell divisions occur that decrease the cells’ size with each subsequent division—this eventually produces a morula. The different cells derived from cleavage, up to the blastula stage, are called blastomeres.
- For species such as humans, there is little yolk in eggs, and the divisions are relatively symmetrical, or holoblastic.
- For other species, such as birds and reptiles, the presence of yolk dictates uneven meroblastic divisions that produce cells of uneven size and distribution.
- The end of cleavage is known as the midblastula transition and coincides with the onset of zygotic transcription.
- The cells of the morula are at first closely aggregated, but quickly become arranged into an outer or peripheral layer, the trophoblast, which does not contribute to the formation of the embryo proper, and an inner cell mass from which the embryo develops.
Key Terms
- cleavage: In embryology, this is the division of cells in the early embryo.
- trophoblast: The membrane of cells that forms the wall of a blastocyst during early pregnancy and provides nutrients to the embryo, and later develops into part of the placenta.
- zygote: A fertilized egg cell.
- morula: A spherical mass of blastomeres that forms following the splitting of a zygote; it becomes the blastula.
Cell division with no significant growth that produces a cluster of cells that is the same size as the original zygote, is called cleavage. At least four initial cell divisions occur, resulting in a dense ball of at least sixteen cells called the morula.
The different cells derived from cleavage up to the blastula stage are called blastomeres. Depending mostly on the amount of yolk in the egg, the cleavage can be holoblastic (total) or meroblastic (partial).
Cell cleavage: Early development is characterized by cleavage of the zygote, which refers to cell divisions that are not associated with significant growth of the embryo.
Holoblastic cleavage occurs in animals with little yolk in their eggs. These species, such as humans and other mammals, receive nourishment as embryos from the mother via the placenta or milk after birth.
On the other hand, meroblastic cleavage occurs in animals whose eggs have more yolk, such as birds and oviparous reptiles (although some viviparous reptiles also exist). Since cleavage is impeded by the vegetal pole, there is a very uneven distribution and size of cells. Cells are more numerous and smaller at the animal pole of the zygote than at the vegetal pole.
In holoblastic eggs, the first cleavage always occurs along the vegetal–animal axis of the egg, and the second cleavage is perpendicular to the first. From here, the spatial arrangement of blastomeres can follow various patterns, due to different planes of cleavage in various organisms.The end of cleavage is known as the midblastula transition and coincides with the onset of zygotic transcription.
In amniotes, the cells of the morula are at first closely aggregated. However, they quickly become arranged into an outer or peripheral layer, the trophoblast, and an inner cell mass. The trophoblast does not contribute to the formation of the embryo proper; the embryo develops from the inner cell mass.
Fluid collects between the trophoblast and the greater part of the inner cell mass, and thus the morula, is converted into the blastodermic vesicle (also called the blastocyst or blastula). The inner cell mass remains in contact with the trophoblast at one pole of the ovum. This is named the embryonic pole, since it indicates the location where the future embryo will develop.
In the case of monozygotic twins (derived from one zygote), a zygote divides into two separate cells (embryos) at the first cleavage division. Monozygotic twins can also develop from two inner cell masses.
A rare occurrence is the division of a single inner cells mass giving rise to twins. However, if one inner cell mass divides incompletely, the result is conjoined twins. Dizygotic twins is the development of two embryos from two different zygotes.
Blastocyst Formation
The blastocyst forms early in embryonic development and has two layers that form the embryo and placenta.
LEARNING OBJECTIVES
Outline the process of blastocyst formation
KEY TAKEAWAYS
Key Points
- The human blastocyst possesses an inner cell mass (ICM), or embryoblast, which subsequently forms the embryo, and an outer layer of cells, or trophoblast, which later forms the placenta.
- The trophoblast surrounds the inner cell mass and a fluid-filled, blastocyst cavity known as the blastocoele or the blastocystic cavity. The trophoblast combines with the maternal endometrium to form the placenta in eutherian mammals.
- Before gastrulation, the cells of the trophoblast become differentiated into two strata: the ectoderm of the chorion plays a role in the development of the placenta, and the endoderm differentiates and quickly assumes the form of a small sac, called the yolk sac.
- The embryoblast is the source of embryonic stem cells and gives rise to all later structures of the adult organism.
- The floor of the amniotic cavity is formed by the embryonic disk, which is composed of a layer of prismatic cells, and the embryonic ectoderm, which is derived from the inner cell mass and lies in opposition to the endoderm.
Key Terms
- embryonic disk: The floor of the amniotic cavity is formed by the embryonic disk (or disc) that is composed of a layer of prismatic cells called the embryonic ectoderm. It is the part of the inner cell mass from which the embryo is developed.
- blastocyst: An early form in the development of an embryo that consists of a spherical layer of cells filled with fluid.
- gastrulation: The stage of embryonic development when a gastrula is formed from the blastula by the inward migration of cells.
- eutherian: Refers to all species of which the female gives birth to live young that receive prenatal nourishment via the placenta.
In humans, the blastocyst is formed approximatelyy five days after fertilization. This stage is preceded by the morula. The morula is a solid ball of about 16 undifferentiated, spherical cells. As cell division continues in the morula, the blastomeres change their shape and tightly align themselves against each other. This is called compaction and is likely mediated by cell surface adhesion glycoproteins.
The blastocyst possesses an inner cell mass (ICM), or embryoblast, which subsequently forms the embryo, and an outer layer of cells, or trophoblast, which later forms the placenta. The trophoblast surrounds the inner cell mass and a fluid-filled, blastocyst cavity known as the blastocoele or the blastocystic cavity.
The embryoblast is the source of embryonic stem cells and gives rise to all later structures of the adult organism. The trophoblast combines with the maternal endometrium to form the placenta in eutherian mammals.
Blastocyst: The blastocyst possesses an inner cell mass from which the embryo will develop, and an outer layer of cells, called the trophoblast, which will eventually form the placenta.
Before gastrulation, the cells of the trophoblast become differentiated into two strata. The outer stratum forms a syncytium, which is a layer of protoplasm studded with nuclei that shows no evidence of subdivision into cells (termed the syncytiotrophoblast).
The inner layer, the cytotrophoblast or layer of Langhans, consists of well-defined cells. As already stated, the cells of the trophoblast do not contribute to the formation of the embryo proper; they form the ectoderm of the chorion and play an important part in the development of the placenta.
On the deep surface of the inner cell mass, a layer of flattened cells, called the endoderm, is differentiated and quickly assumes the form of a small sac, called the yolk sac. Spaces appear between the remaining cells of the mass and, by the enlargement and coalescence of these spaces, a cavity called the amniotic cavity is gradually developed.
The floor of this cavity is formed by the embryonic disk, which is composed of a layer of prismatic cells called the embryonic ectoderm. This layer is derived from the inner cell mass and lies in opposition to the endoderm.
Implantation
Implantation is the very early stage of pregnancy at which the embryo adheres to the wall of the uterus and begins to form the placenta.
LEARNING OBJECTIVES
Outline the process of implantation in pregnancy
KEY TAKEAWAYS
Key Points
- At this stage of prenatal development the embryo is a blastocyst. In humans, implantation of a fertilized ovum occurs between 6 to 12 days after ovulation.
- In preparation for implantation, the blastocyst sheds its outside layer, the zona pellucida, and is replaced by a layer of underlying cells called the trophoblast. The trophoblast will give rise to the placenta after implantation.
- During implantation, the trophoblast differentiates into two distinct layers: the inner cytotrophoblast, and the outer syncytiotrophoblast. The syncytiotrophoblast then implants the blastocyst into the endometrium by forming finger-like projections into the uterine wall called chorionic villi.
Key Terms
- endometrium: The mucous membrane that lines the uterus in mammals and in which fertilized eggs are implanted.
- trophoblast: The membrane of cells that forms the wall of a blastocyst during early pregnancy and provides nutrients to the embryo and later develops into part of the placenta.
- human chorionic gonadotropin (hCG): In molecular biology, human chorionic gonadotropin (hCG) is a hormone produced during pregnancy that is made by the developing placenta after conception, and later by the placental component.
- implantation: The embedding of the blastocyst to the uterine wall.
Implantation is the very early stage of pregnancy during which the embryo embeds into the wall of the uterus. At this stage of prenatal development, the embryo is a blastocyst.
It is by this adhesion that the fetus receives oxygen and nutrients from the mother to be able to grow. In humans, implantation of a blastocyst occurs between 6 to 12 days after ovulation.
In preparation for implantation, the blastocyst sheds its outside layer, the zona pellucida, which binds sperm during fertilization. The zona pellucida degenerates and decomposes, and is replaced by a layer of underlying cells called the trophoblast.
The trophoblast will give rise to the placenta after implantation. During implantation, the trophoblast differentiates into two distinct layers: the inner cytotrophoblast, and the outer syncytiotrophoblast.
Chorionic villi: During implantation, extensions of the trophoblast, the syncytiotrophoblasts, embed within the endometrium and form chorionic villi.
The syncytiotrophoblast then implants the blastocyst into the endometrium of the uterus by forming finger-like projections into the uterine wall called chorionic villi. The chorionic villi grow outwards until they come into contact with the maternal blood supply.
The chorionic villi will be the border between maternal and fetal blood during the pregnancy, and the location of gas and nutrient exchange between the fetus and the mother. The creation of chorionic villi is assisted by hydrolytic enzymes that erode the uterine epithelium.
The syncytiotrophoblast also produces human chorionic gonadotropin (hCG), a hormone that notifies the mother’s body that she is pregnant and prevents menstruation by sustaining the function of the progesterone-producing corpus luteum within the ovary.
Human chorionic gonadotropin is the hormone that is detected by pregnancy tests, as it is found in the maternal bloodstream and urine.
