【佳學基因檢測】缺氧誘導的巢蛋白通過靶向轉(zhuǎn)錄因子 Nrf2、STAT3 和 SOX2 調(diào)節(jié)肺癌的活力和代謝

腫瘤基因檢測多少錢原理

學習認識到《Comput Intell Neurosci》在.?2022 Aug 30;2022:9811905.發(fā)表了一篇題目為《缺氧誘導的巢蛋白通過靶向轉(zhuǎn)錄因子 Nrf2、STAT3 和 SOX2 調(diào)節(jié)肺癌的活力和代謝》腫瘤靶向藥物治療基因檢測臨床研究文章。該研究由Yongshi Liu,?Xinglin Zhang,?Tao Jiang,?Ning Du?等完成。促進了腫瘤的正確治療與個性化用藥的發(fā)展，進一步強調(diào)了基因信息檢測與分析的重要性。

腫瘤靶向藥物及正確治療臨床研究內(nèi)容關鍵詞：

腫瘤靶向治療基因檢測臨床應用結(jié)果

目的：探討低氧誘導的Nestin通過靶向轉(zhuǎn)錄因子Nrf2、STAT3和SOX2調(diào)控肺癌細胞活力和代謝。方法：84例非小細胞肺癌（nonsmall cell lung cancer, NSCLC）治療2020 年 6 月至 2021 年 2 月，從我們的臨床病理學數(shù)據(jù)庫中隨機選擇。對收集的組織細胞進行免疫組織化學染色，以評估巢蛋白、STAT3、Nrf2 和 SOX2 的表達模式。使用單因素和雙因素方差分析對數(shù)據(jù)進行量化和統(tǒng)計分析，P < 0.05。 Nestin表達與STAT3、Nrf2、SOX2表達相關。Nestin/STAT3/SOX2/Nrf2參與血管生成和肺癌發(fā)生發(fā)展。結(jié)論：缺氧誘導的Nestin通過靶向下游轉(zhuǎn)錄因子STAT3促進非小肺癌細胞的進展， Nrf2 和 SOX2。

腫瘤發(fā)生與反復轉(zhuǎn)移國際數(shù)據(jù)庫描述：

Objective:?To investigate hypoxia-induced Nestin regulates lung cancer viability and metabolism by targeting transcription factors Nrf2, STAT3, and SOX2.Methods:?Eighty-four cases of nonsmall cell lung cancer (nonsmall cell lung cancer, NSCLC), which had been treated from June 2020 to February 2021, were randomly selected from our clinicopathology database. Immunohistochemical staining of collected tissue cells was performed to assess the expression patterns of Nestin, STAT3, Nrf2, and SOX2. Data were quantified and statistically analyzed using one-way and two-way ANOVA tests with?P?< 0.05.Results:?Clinicopathological findings showed significant differences in lymph node metastasis, tissue differentiation, and histology on induction of Nestin expression; Nestin expression correlated with STAT3, Nrf2, and SOX2 expression.Nestin/STAT3/SOX2/Nrf2 are involved in angiogenesis and lung cancer development.Conclusion:?Hypoxia-induced Nestin promotes the progression of nonsmall lung cancer cells by targeting the downstream transcription factors STAT3, Nrf2, and SOX2.